Graduate Research Opportunities
- I am no longer accepting new graduate or undergraduate students.
Genomics of Bacterial Diseases in Broilers: Early Chick Infection; Lameness from Bacterial Chrondronecrosis and Osteomyelitis (BCO)
Originally in collaboration with Dr. Robert Wideman, and now in collaboration with Dr. Adnan Alrubaye in Poultry Science, we are investigating the bacteria involved in BCO as found in lame chickens. Dr. Wideman developed a wire-floor model for inducing lameness. Our laboratory contributed through molecular identification of bacteria isolated from necrotic lesions of the femoral and tibial heads. With Dr. Alrubaye we have developed methods to understand the spread of the infection within a flock and to develop management methods to reduce or eliminate the spread. We have developed a bacterial epidemic model for the spread of BCO lameness in broilers on litter flooring to mimic the spread of the infection. We use the wire-flooring to spread the infection to birds on litter-flooring. This allows us to identify management strategies, and feed supplements to prevent the spread of the infection. Our lab has extended the work on bacterial genomics to examine pathogen evolution and mobile elements involved in host and niche adaptation. We are now focused on bacteria infecting the embryo and early chick.
Molecular Genomics in Non-Model Organisms
With Dr. Steve Beaupré and a consortium of investigators we sequenced and assembled the genome for Crotalus horridus (Timber Rattlesnake) in the Southeastern United States.
With Dr. Tsunemi Yamashita (Arkansas Tech University) we sequenced and assembled the genome for Centroides vittatus (scorpion) to understand its phylogenomics and toxin repertoire.
Current projects are underway to sequence and assemble genomes for two additional snakes and two spiders.
Genetics of Pulmonary Hypertension Syndrome
In collaboration with Dr. Orlowski, in Poultry Science, we mapped genes affecting resistance and susceptibility to Ascites; a.k.a. Idiopathic Pulmonary Arterial Hypertension (IPAH), or Pulmonary Hypertension Syndrome (PHS). This disease affects meat-type chickens and is similar to the disease in humans. We identified 28 regions that segregate with resistance. We used Marker Assisted Selection based on two of these regions to demonstrate that we could select for enhanced resistance to ascites. This project is no longer active
This project was supported by grants from USDA 2016-2021.