Journal Publications
Bullard, E.A., Mundo, A.I., Bess, S.N., Priest, K.M., Muldoon, T.J., “Minimally invasive in vivo endoscopic monitoring of dextran sulfate sodium-induced murine colitis” MethodsX, 9: 101744 (2022) Download
Bess, S.N., Greening, G.J., Rajaram, N., Muldoon, T.J., “Macrophage-targeted anti-CCL2 immunotherapy enhances tumor sensitivity to 5-fluorouracil in a Balb/c-CT26 murine colon carcinoma model measured using diffuse reflectance spectroscopy” BMC Immunology, 23 (20) (2022) Download
Ahmed, M., Muldoon, T.J., Elsaadany, M.,”Employing Faculty, Peer Mentoring, and Coaching to Increase the Self-Confidence and Belongingness of First-Generation College Students in Biomedical Engineering”, Journal of Biomechanical Engineering, 143(12): 121001 (2021) Download
Mundo, A.I., Tipton, J.R., Muldoon, T.J., “Using generalized additive models to analyze biomedical non-linear longitudinal data”, bioRxiv 2021.06.10.447970 (2021) Download
Powless, A.J., Prieto, S.P., Gramling, M.R., Chen, J., Muldoon, T.J., “A Light-Sheet-Based Imaging Spectrometer to Characterize Acridine Orange Fluorescence within Leukocytes” Diagnostics, 10, 1082 (2020) Download
Tandon, I., Johns, S., Woessner, A., Perez, J., Cross, D., Ozkizilcik, A., Muldoon, T.J., Vallurupalli, S., Padala, M., Quinn, K.P., Balachandran, K., “Label-free optical biomarkers detect early calcific aortic valve disease in a wild-type mouse model”, BMC Cardiovasc Disord 20, 521 (2020) Download
Mundo, A.I., Greening, G.J., Fahr, M.J., Hale, L.N., Bullard, E.A., Rajaram, N., Muldoon, T.J., “Diffuse reflectance spectroscopy to monitor murine colorectal tumor progression and therapeutic response”, Journal of Biomedical Optics, 25(3) 035002 (2020) Download
Bess, S.N., Greening, G.J. Muldoon, T.J., “Efficacy and clinical monitoring strategies for immune checkpoint inhibitors and targeted cytokine immunotherapy for locally advanced and metastatic colorectal cancer,” Cytokine and Growth Factor Reviews, 49:1-9 (2019) Download
Greening, G.J., Mundo, A.I., Rajaram, N., Muldoon, T.J., “Sampling depth of a diffuse reflectance spectroscopy probe for in-vivo physiological quantification of murine subcutaneous tumor allografts,” Journal of Biomedical Optics, 23(8), 085006. (2018) Download
Greening, G.J., Miller, K.P., Spainhour, C.R., Cato, M.D., Muldoon, T.J., “Effects of isoflurane anesthesia on physiological parameters in murine subcutaneous tumor allografts measured via diffuse reflectance spectroscopy,” Biomedical Optics Express, 9(6), 2871-2886. (2018) Download
Tabassum, S., Pera, V., Greening, G.J., Muldoon, T.J., Roblyer, D., “Two-layer inverse model for improved longitudinal preclinical tumor imaging in the spatial frequency domain,” Journal of Biomedical Optics, 23(7), 076011. (2018) Download
Prieto, S.P., Lai, K.K., Laryea, J.A., Mizell, J.S., Mustain, W.C., Muldoon, T.J., “Fluorescein as a topical fluorescent contrast agent for quantitative microendoscopic inspection of colorectal epithelium,” Biomedical Optics Express, 8(4), 2324-2338. (2017) Download
Powless, A.J., Conley, R.J., Freeman, K.A., Muldoon, T.J., “Considerations for point-of-care diagnostics: evaluation of acridine orange staining and postprocessing methods for a three-part leukocyte differential test,” Journal of Biomedical Optics, 22(3), 035001. (2017) Download
Alhallak, K., Rebello, L.G., Muldoon, T.J., Quinn, K.P., Rajaram, N., “Optical redox ratio identifies metastatic potential-dependent changes in breast cancer cell metabolism,” Biomedical Optics Express, 7(11), 4365-4374. (2016) Download
Greening, G.J., Rajaram, N., Muldoon, T.J., “Multimodal imaging and spectroscopy fiber-bundle microendoscopy platform for non-invasive, in vivo tissue analysis,” Journal of Visualized Experiments, (116), e54564. (2016) Download
Greening, G.J., James, H.M., Dierks, M.K., Vongkittiargorn, N., Osterholm, S.M., Rajaram, N., Muldoon, T.J., “Towards monitoring dysplastic progression in the oral cavity using a hybrid fiber-bundle imaging and spectroscopy probe,” Scientific Reports, 6:26734. (2016) Download
Prieto, S., Lai, K., Laryea, J., Mizell, J., Muldoon, T.J., “Quantitative analysis of ex vivo colorectal epithelium using an automated feature extraction algorithm for microendoscopy image data,” Journal of Medical Imaging, 3(2), 024502. (2016) Download
Jenkins, S., Meeker, D., Miller, E., Beenken, K., Loughran, A., Powless, A., Muldoon, T.J., Galanzha, E., Zharov, V., Smeltzer, M.S., Chen, J.S., “Synergistic photothermal and antibiotic killing of biofilm-associated staphylococcus aureus using targeted, antibiotic-loaded gold nanoconstructs,” ACS Infectious Diseases, 2(4), 241–250. (2016) Download
Greening, G.J., James, H.J., Muldoon, T.J., “Optical Phantoms: Diffuse and sub-diffuse imaging and spectroscopy validation,” SPIE Spotlights, 1-40. (2016) Download
Greening, G.J., Powless, A.J., Hutcheson, J.A., James, H.M., Diekrs, M.K., Rajaram, N., Muldoon, T.J., “Fiber-bundle microendoscopy with sub-diffuse reflectance spectroscopy and intensity mapping for multimodal optical biopsy of stratified epithelium,” Biomedical Optics Express, 6(12), 4934-50. (2015) Download
Hutcheson, J.A., Majid, A.A., Powless, A.J., Muldoon, T.J., “A widefield fluorescence microscope with a linear image sensor for image cytometry of biospecimens: considerations for image quality optimization” Review of Scientific Instruments, 86(9), 093709. (2015) Download
Prieto, S.P., Powless, A.J., Boice, J.W., Sharma, S.G., Muldoon, T.J., “Proflavine hemisulfate as a fluorescent contrast agent for point-of-care cytology,” PLoS One, 10(5), 1-15. (2015) Download
Greening, G.J., Istfan, R., Higgins, L.M., Balachandran, K., Roblyer, D., Pierce, M.C., Muldoon, T.J., “Characterization of thin poly (dimethylsiloxane)-based tissue simulating phantoms with tunable reduced scattering and absorption coefficients at visible and near infrared wavelengths,” Journal of Biomedical Optics, 19(11), 115002. (2014) Download
Muldoon, T.J., Burgess, S., Chen, B., Ratner, D., Hillman, E.M.C., “Analysis of skin lesions using laminar optical tomography,” Biomedical Optics Express, 3(7), 1701-1712. (2012) Download
Muldoon, T.J., Roblyer, D., Williams, M.D., Stepanek, V.M.T., Richards-Kortum, R., Gillenwater, A.M. “Non-invasive imaging of oral neoplasia with a high-resolution fiber optic microendoscope.” Head and Neck, 34(3), 305-312. (2012) Download
Thekkek, N., Muldoon, T.J., et al. “Vital-dye enhanced fluorescence imaging of gastrointestinal mucosa: metaplasia, neoplasia, inflammation.” Gastrointestinal Endoscopy, 75(4), 877-87. (2012) Download
Rosbach, K., Shin, D., Muldoon, T.J., et al. “High-resolution fiber optic microscopy with fluorescent contrast enhancement for the identification of axillary lymph node metastases in breast cancer: a pilot study.” Biomedical Optics Express. 1(3), 911-922. (2010) Download
Muldoon, T.J., Thekkek, N., Roblyer, D., et al. “Evaluation of quantitative image analysis criteria for the high-resolution micro-endoscopic detection of neoplasia in Barrett’s esophagus,” Journal of Biomedical Optics, 15(2): 026027. (2010) Download
Nitin, N., Carlson, A.L., Muldoon, T.J., et al. “Molecular imaging of glucose uptake in oral neoplasia following topical application of fluorescently labeled deoxy-glucose,” International Journal of Cancer, 124(11), 2634-42. (2009) Download
Muldoon, T.J., Anandasabapathy, S., Maru, D., and Richards-Kortum, R. “High-resolution imaging in Barrett’s Esophagus: a novel, low-cost endoscopic microscope,” Gastrointestinal Endoscopy, 68(4), 737-44. (2008) Download
Muldoon, T.J., Pierce, M., Nida, D., Williams, M., Gillenwater, A. and Richards-Kortum, R. “Subcellular-resolution molecular imaging within living tissue by fiber microendoscopy,” Optics Express, 15(25), 16413-16423. (2007) Download
Proceedings Papers/Conference Presentations
Mundo, A.I., Muldoon, T.J.,”Longitudinal optical and molecular quantification provides insight into the effect of different dosing strategies in colorectal cancer” Biophotonics Congress: Biomedical optics 2022 (Translational, Microscopy, OCT, OTS, BRAIN)
Bess, S.N., Muldoon, T.J., Abstract P009: Correlation between immune modulation of macrophage recruitment and new blood vessel formation in a subcutaneous murine mouse model of colorectal cancer, Abstracts: AACR Virtual Special Conference: Tumor Immunology and Immunotherapy, Cancer Immunol Res 2022;10(1 Suppl):Abstract nr P009. Download
Elsaadany, M., Muldoon, T.J., Rao, RR”Instructional and learning opportunities for remote offerings of integrated lab-lecture core undergraduate biomedical engineering courses”, Paper presented at 2021 ASEE Midwest Section Conference, Virtual. 10.18260/1-2-1128.1153-38319 (2021) Download
Nicholson, A.G., Rathke, N., Boyd, E., Magness, M.L., Khan, F.Z., Steward, A., Muldoon, T.J., Haggard, B., Fritsch, I., “Manipulating Microvolumes of Fluids By Redox-Magnetohydrodynamics for Applications in Chemical Analysis”, ECS Meeting Abstracts, 60(16010) (2021) Download
Mundo, A.I., Muhammad, A., Muldoon, T.J., “Optical and molecular longitudinal tracking of primary colorectal murine tumors shows differences in the angiogenic response to maximum-tolerated and metronomic approaches”, Proc. SPIE 11655, Label-free Biomedical Imaging and Sensing (LBIS) 2021, 116551C (5 March 2021); Download
Mundo, A.I., Greening, G.J., Muldoon T.J., Characterization of a multimodal endoscopically deployable veterinary spectroscopy and imaging probe to determine therapeutic response in a murine orthotopic tumor model. SPIE BiOS. Vol. 10890. 2019: SPIE.
Prieto, S.P., Greening, G.J., Lai, K.K., Muldoon, T.J., “Quantitative structural markers of colorectal dysplasia in a cross sectional study of ex vivo murine tissue using label-free multiphoton microscopy,” Proceedings of SPIE, Vol. 9712. (2016) Download
Powless, A.J., Feekin, L.E., Hutcheson, J.A., Alapat, D.V., Muldoon, T.J., “Low-cost computing and network communication for a point-of-care device to perform a 3-part leukocyte differential,” Proceedings of SPIE, Vol. 9715. (2016) Download
Greening, G.J., Rajaram, N., Muldoon, T.J., “In vivo measurement of non-keratinized squamous epithelium using a spectroscopic microendoscope with multiple source-detector separations,” Proceedings of SPIE, Vol. 9715. (2016) Download
Hutcheson, J.A., Khan, F.Z., Powless, A.J., Benson, D., Hunter, C.J., Fritsch, I., Muldoon, T.J., “A light sheet confocal microscope for image cytometry with a variable linear slit detector,” Proceedings of SPIE, Vol. 9720. (2016) Download
Prieto, S.P., Powless, A.J., Lai, K.K., Laryea, J.A., Mizell, J.S., Muldoon, T.J., “Qualitative and quantitative comparison of colonic microendoscopy image features to histopathology,” Proceedings of SPIE, Vol. 9328. (2015) Download
Powless, A.J., Jenkins, S.V., McKay, M.L., Chen, J., Muldoon, T.J., “Molecule-specific darkfield and multiphoton imaging using gold nanocages,” Proceedings of SPIE, Vol. 9339. (2015) Download
Greening, G.J., Powless, A.J., Hutcheson, J.A., Prieto, S.P., Majid, A.A., Muldoon, T.J., “Design and validation of a diffuse reflectance and spectroscopic microendoscope with poly (dimethylsioxane)-based phantoms,” Proceedings of SPIE, Vol. 9332. (2015) Download
Hutcheson, J.A., Powless, A.J., Majid, A.A., Claycomb, A., Fritsch, I., Balachandran, K., Muldoon, T.J., “High-throughput microfluidic line scan imaging for cytological characterization,” Proceedings of SPIE, Vol. 9320. (2015) Download
Pierce, M.C., Schwarz, R.A., Rosbach, K., Roblyer, D., Muldoon, T.J., et al. “Wide-field and high-resolution optical imaging for early detection of oral neoplasia,” Proceedings of SPIE, Vol. 7548C-68. (2010) Download
Richards-Kortum, R., Pierce, M., Vestewig, L., Muldoon, T.J., Rahman, M., “Global approaches to cancer prevention,” SPIE Newsroom, (2009) Download